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Differentiable Systems and Scientific Machine Learning

A workshop @ EurIPS 2025

December 6, 2025

Bella Center, Aud. 11

About

Automatic differentiation is a key technology for most machine learning models and inverse problems, including surrogate models that simulate + optimize complex scientific phenomena. But can we go beyond individual models?

More precisely, can we build entire differentiable systems that combine multiple components such as adjoint-based simulators, mathematical solvers, surrogate models, and 3D renderers to tackle real scientific challenges?

This workshop aims to answer that question by bringing together experts from around the community. We expect contributions that present advances in:

(See Call for Papers for more details)

Important dates

Schedule

All times below are local to the workshop (GMT+2).

TimeEvent
08:30 - 08:45Authors put up posters
08:45 - 09:00 Opening remarks
09:00 - 09:45Invited Talk
Petros Koumoutsakos — Simulation and Control of forward and inverse problems using the Optimisation of a Discrete Loss (ODIL)
09:45 - 10:30Invited Talk
Johanna Haffner — An introduction to the Equinox ecosystem: differentiable optimization + scientific computing in JAX
10:30 - 11:00Coffee Break
11:00 - 12:30 Contributed Talks (selected from submissions, 10+2 min each)
  1. scipy.spatial.transform: Differentiable Framework-Agnostic 3D Transformations in Python
  2. Train Forwards, Optimize Backwards: Neural Surrogates for Personalized Medical Simulations
  3. DiffWake: A General Differentiable Wind-Farm Solver in JAX
  4. Surrogate-Based Differentiable Pipeline for Shape Optimization
  5. Carbox: an end-to-end differentiable astrochemical simulation framework
  6. Douglas-Rachford Splitting for Hybrid Differentiable Models
12:30 - 13:30Lunch Break
13:30 - 14:15Invited Talk
Sai Bangaru — Developing Performance-Critical Differentiable Software With Slang
14:15 - 15:00 Invited Talk
Astrid Walle — Learning from CAD
15:00 - 15:30Coffee Break
15:30 - 16:15 Panel Discussion
System approaches in SciML — key to real-world impact or intractable complexity?

Panelists: Astrid Walle, Dirk Hartmann, Johanna Haffner, Petros Koumoutsakos, Sai Bangaru

16:15 - 17:00Poster Session

🚨 Post-workshop event: Differentiable systems with Tesseract 🚨

Join some of the organizers (and hopefully many of the attendees) for pizza, drinks, and a tutorial on how to use Tesseract to build end-to-end differentiable systems.

More information and registration on Luma.

Accepted Workshop Papers

  1. LOCO: Abstracting Spectral Numerical Integrators for PDEs into Neural OperatorsLenz Pracher, Takashi Matsubara [OpenReview] [PDF]
  2. Acoustic field estimation with differentiable physicsSamuel Arturo Verburg Riezu, Efren Fernandez Grande, Peter Gerstoft [OpenReview] [PDF]
  3. Improving Long-Range Interactions in Graph Neural Simulators via Hamiltonian DynamicsTai Hoang, Alessandro Trenta, Alessio Gravina, Niklas Freymuth, Philipp Becker, Davide Bacciu, Gerhard Neumann [OpenReview] [PDF]
  4. Differentiable N-body code for Galactic Dynamics - OdisseoGiuseppe Viterbo, Tobias Buck [OpenReview] [PDF]
  5. Ray-trax: Fast, Time-Dependent and Differentiable Ray Tracing for On-the-Fly Radiative Transfer in Turbulent Astrophysical FlowsLorenzo Branca, Rune Rost, Tobias Buck [OpenReview] [PDF]
  6. Emulating Radiative Transfer in Astrophysical EnvironmentsRune Rost, Lorenzo Branca, Tobias Buck [OpenReview] [PDF]
  7. Accelerating Automatic Differentiation of Direct Form Digital FiltersChin-Yun Yu, George Fazekas [OpenReview] [PDF]
  8. Graph Neural Regularizers for PDE Inverse ProblemsWilliam Lauga, James Rowbottom, Alexander Denker, Zeljko Kereta, Moshe Eliasof, Carola-Bibiane Schönlieb [OpenReview] [PDF]
  9. An Empirical Study of Lagrangian Methods in Safe Reinforcement LearningLindsay Spoor, Alvaro Serra-Gomez, Aske Plaat, Thomas M. Moerland [OpenReview] [PDF]
  10. Dynamic guessing for Hamiltonian Monte Carlo with embedded numerical root-findingTeddy Groves, Nicholas Luke Cowie, Lars Keld Nielsen [OpenReview] [PDF]
  11. Are gradients worth the effort? Comparing automatic differentiation and simulation-based inference for agent-based modelsTimothy James Hitge, Arnau Quera-Bofarull, Elizaveta Semenova [OpenReview] [PDF]
  12. Data-Guided Discovery of Ocean DynamicsQi-fan Wu, Dion Häfner, Roman Nuterman, Guido Vettoretti, Markus Jochum [OpenReview] [PDF]
  13. When Less is More: Approximating the Quantum Geometric Tensor with Block StructuresAhmedeo Shokry, Alessandro Santini, Filippo Vicentini [OpenReview] [PDF]
  14. First-order Sobolev Reinforcement LearningFabian Schramm, Nicolas Perrin-Gilbert, Justin Carpentier [OpenReview] [PDF]
  15. Improving GNN-Based Multiple Scattering Simulation with RewiringRémi Marsal, Stéphanie Chaillat [OpenReview] [PDF]
  16. Measure-Valued Automatic Differentiation for Hybrid and Non-Smooth SystemsMuhammad Haris Khan [OpenReview] [PDF]
  17. Enhancing scientific Bayesian optimization via physics-informed operator priorsSean Hooten, Wolfger Peelaers, Thomas Van Vaerenbergh, Marco Fiorentino [OpenReview] [PDF]
  18. scipy.spatial.transform: Differentiable Framework-Agnostic 3D Transformations in PythonMartin Schuck, Alexander von Rohr, Angela P. Schoellig [OpenReview] [PDF]
  19. Differentiable AstrophysicsPhilip Mocz [OpenReview] [PDF]
  20. Differentiable Simulations for Joint Parameterised Optimisation of Antenna ArraysNiels Skovgaard Jensen, Frederik Faye, Lasse Hjuler Christiansen, Allan Peter Engsig-Karup [OpenReview] [PDF]
  21. Uncertainty-aware Physics-informed Neural Networks for Robust CARS-to-Raman Signal ReconstructionAishwarya Venkataramanan, Sai Karthikeya Vemuri, Adithya Ashok Chalain Valapil, Joachim Denzler [OpenReview] [PDF]
  22. RUBIX: Differentiable forward modelling of galaxy spectral data cubes for gradient-based parameter estimationAnna Lena Schaible, Ufuk Çakır, Harald Mack, Aura Obreja, William H. Oliver, Nihat Oguz, Horea Cărămizaru, Tobias Buck [OpenReview] [PDF]
  23. Solver-in-the-Loop Applications in Astrophysical (Magneto)hydrodynamicsLeonard Storcks, Tobias Buck [OpenReview] [PDF]
  24. Modeling COVID-19 Dynamics in German States Using Physics-Informed Neural NetworksPhillip Rothenbeck, Sai Karthikeya Vemuri, Niklas Penzel, Joachim Denzler [OpenReview] [PDF]
  25. Temporal stability in reduced order model prediction of sea states: A surrogate model case studyFreja Petersen, Allan Peter Engsig-Karup, Rocco Palmitessa, Jesper Sandvig Mariegaard [OpenReview] [PDF]
  26. Leveraging a Fully Differentiable Integrated Assessment Model for RL and InferenceKoen Ponse, Kai-Hendrik Cohrs, Phillip Wozny, Andrew Robert Williams, Tianyu Zhang, Erman Acar, Yoshua Bengio, Aske Plaat, Thomas M. Moerland, Pierre Gentine, Gustau Camps-Valls [OpenReview] [PDF]
  27. Hybrid solver with local correction using Lagrangian latent memoryGwendal Jouan, Matthias Schulz, Daniel Berger, Stefan Gavranovic, Dirk Hartmann [OpenReview] [PDF]
  28. Real-time optimal control with shallow recurrent decoder networksMatteo Tomasetto, Andrea Manzoni, J. Nathan Kutz [OpenReview] [PDF]
  29. A Validated LBM Dataset and Pipeline for Surrogate Modeling of Turbulent 3D Obstructed Channel FlowsLukas Schröder, Shubham Kavane, Harald Koestler [OpenReview] [PDF]
  30. Predicting Eigenmode Decompositions in Vibroacoustic SystemsChristian Libner, Jan van Delden, Julius Schultz, Alexander S. Ecker, Timo Lüddecke [OpenReview] [PDF]
  31. GPGreen: Learning Linear Operators with Gaussian ProcessesThomas Cowperthwaite, Henry Moss [OpenReview] [PDF]
  32. Enhancing data assimilation and uncertainty quantification: machine learning for better covariance estimationVinicius Luiz Santos Silva, Gabriel Serrao Seabra, Alexandre Anoze Emerick [OpenReview] [PDF]
  33. Hybrid Learning of Transport Equations with Differentiable Neural Solvers from Experimental DataArthur Jessop, Mohammed Alsubeihi, Ashwin Kumar Rajagopalan, Ben Moseley [OpenReview] [PDF]
  34. Towards fully differentiable neural ocean model with VerosEtienne Meunier, Said Ouala, Hugo Frezat, Julien Le Sommer, Ronan Fablet [OpenReview] [PDF]
  35. Learning Soil Water Retention Components through an End-to-End Differentiable Hybrid ModelSarem Norouzi, Per Moldrup, Ben Moseley, David Robinson, Dani Or, Budiman Minasny, Morteza Sadeghi, Tobias L. Hohenbrink, Emmanuel Arthur, Mogens H. Greve, Lis W. de Jonge [OpenReview] [PDF]
  36. Differentiable Top-k: From One-Hot to k-HotKlas Wijk, Ricardo Vinuesa, Hossein Azizpour [OpenReview] [PDF]
  37. Discovering and modelling dynamics on latent manifolds with neural geodesic flowsJulian Bürge, Lewis O'Donnell, Ben Moseley [OpenReview] [PDF]
  38. Train Forwards, Optimize Backwards: Neural Surrogates for Personalized Medical SimulationsJonas Weidner, Ivan Ezhov, Michal Balcerak, Bjoern Menze, Daniel Rueckert, Benedikt Wiestler [OpenReview] [PDF]
  39. Implicit function theorem in Physics-Informed Neural Networks to solve parameterized differential equationsJulien Marie-Anne, Cyriaque Rousselot, Nilo Schwencke, Alena Shilova [OpenReview] [PDF]
  40. Certifying Physics-Informed Neural Networks through Lower Error BoundsArzu Ahmadova, Ismail Huseynov, Agamirza Bashirov [OpenReview] [PDF]
  41. Differentiation Strategies for Acoustic Inverse Problems: Admittance Estimation and Shape OptimizationNikolas Borrel-Jensen, Josiah Bjorgaard [OpenReview] [PDF]
  42. Bridging Continuous and Discrete Physics: A Hybrid PINN Framework with Differentiable SolversGuillermo Ricardo Moreno Carrillo [OpenReview] [PDF]
  43. Case study of a differentiable heterogeneous multiphysics solver for a nuclear fusion applicationJack Coughlin, Jonathan Brodrick, Archis Joglekar, Alexander Lavin [OpenReview] [PDF]
  44. A Comparative Empirical Study of Relative Embedding Alignment in Neural Dynamical System ForecastersDeniz Kucukahmetler, Maximilian Jean Hemmann, Julian Mosig von Aehrenfeld, Maximilian Amthor, Christian Deubel, Nico Scherf, Diaaeldin Taha [OpenReview] [PDF]
  45. DiffWake: A General Differentiable Wind Farm Solver in JAXMaria Bånkestad, Leon René Sütfeld, Aleksis Pirinen, Hamidreza Abedi [OpenReview] [PDF]
  46. Autoregressive PINNs for Time-Dependent PDEsMayank Nagda, Jephte Abijuru, Phil Ostheimer, Jan C. Aurich, Stephan Mandt, Marius Kloft, Sophie Fellenz [OpenReview] [PDF]
  47. Data and Modeling Assumptions in Physics-Informed Operator LearningMartin Hofmann-Wellenhof, Alexander Fuchs, Bernhard C Geiger, Franz Pernkopf [OpenReview] [PDF]
  48. Amortized Physics-Informed Learning via Generative Initialization of Radial Basis FunctionsEdgar Torres, Mathias Niepert [OpenReview] [PDF]
  49. Surrogate-Based Differentiable Pipeline for Shape OptimizationAndrin Rehmann, Nolan Black, Josiah Bjorgaard, Alessandro Angioi, Andrei Paleyes, Niklas Heim, Dion Häfner, Alexander Lavin [OpenReview] [PDF]
  50. Hybridized Data Driven Flux-Conservative Solvers: Towards Foundation Models for PDE-SolvingDirk Hartmann [OpenReview] [PDF]
  51. A differentiable model of supply-chain shocksSebastian Rene Towers, José Moran, Saad Hamid, Luca Mungo, Arnau Quera-Bofarull [OpenReview] [PDF]
  52. Carbox: an end-to-end differentiable astrochemical simulation frameworkGijs Vermariën, Tommaso Grassi, Marie Van de Sande, Serena Viti, Stefano Bovino, Alessandro Lupi, Alexander Ruf, Lorenzo Branca, Catherine Walsh [OpenReview] [PDF]
  53. Physics-Informed Residual FlowsJephte Abijuru, Mayank Nagda, Phil Ostheimer, Jan C. Aurich, Sebastian Josef Vollmer, Marius Kloft, Sophie Fellenz [OpenReview] [PDF]
  54. Spherical Fourier Neural Operators for Cosmic Microwave Background DelensingAlessio Spurio Mancini [OpenReview] [PDF]
  55. Sumudu Neural Operator for ODEs and PDEsBenjamin Zelenskiy, Saibilila Abudukelimu, George Flint, Kevin Zhu, Sunishchal Dev [OpenReview] [PDF]
  56. WARP-LUTs - Walsh-Assisted Relaxation for Probabilistic Look Up TablesLino Gerlach, Liv Helen Våge, Thore Gerlach, Elliott Kauffman, Isobel Ojalvo [OpenReview] [PDF]
  57. SQUID: A Bayesian Approach for Physics-Informed Event ModelingSumantrak Mukherjee, Sebastian Josef Vollmer, Gerrit Großmann [OpenReview] [PDF]
  58. Approximating Hermitian Yang--Mills connections on vector bundlesJustin Tan
  59. Douglas-Rachford Splitting for Hybrid Differentiable ModelsAbdel-Rahim Mezidi, Jordan Patracone, Amaury Habrard [OpenReview] [PDF]

Invited Speakers

Petros Koumoutsakos

Petros Koumoutsakos

Professor of Computing in Science and Engineering, Harvard University, and a leading expert in AI for science.

Johanna Haffner

Johanna Haffner

Johanna is a maintainer of Optimistix and an active contributor to scientific computing libraries in the Equinox ecosystem in JAX. She is currently a PhD researcher in systems biology at ETH Zurich.

Sai Bangaru

Sai Bangaru

Research Scientist at NVIDIA working on GPU programming languages for performance-critical differentiable software. A core developer of the Slang shading language.

Astrid Walle

Astrid Walle

Astrid Walle is a mechanical engineer with a PhD in CFD and more than a decade of experience in applied fluid mechanics. She has held several positions in gas turbine R&D and AI development at Siemens Energy, Vattenfall and Rolls Royce. She's driven to bring AI and Data Science into engineering and to use data in product development from the very beginning.

Call for Papers

We invite previously unpublished submissions in a form of short papers, including those describing work in progress, as long as they represent advances within one or more of the following topics:

Submission Guidelines

Submission website: Submit on OpenReview

Further Reading

Want to learn more about differentiable systems and scientific machine learning? Here are some pointers to get you started:
  1. Physics-Based Deep Learning
  2. Machine Learning for Fluid Mechanics
  3. SciML: Open Source Software for Scientific Machine Learning
  4. Tesseract Core: Universal, autodiff-native software components for Simulation Intelligence
  5. Automatic Differentiation in Machine Learning: a Survey

Organizers

Andrei Paleyes

Andrei Paleyes

Pasteur Labs

Dion Häfner

Dion Häfner

Pasteur Labs

Sam Alipio

Sam Alipio

Pasteur Labs

Felix Köhler

Felix Köhler

Technical University Munich

Jan-Willem van de Meent

Jan-Willem van de Meent

University of Amsterdam

Contact: differentiable-systems@googlegroups.com